PLGA纳米粒抗肿瘤药物载体的研究进展

摘要

Objective To summarize the progress in the study of poly (lactide-co-glycolide) (PLGA ) nanoparticles for delivery of anticancer agents .Method The latest domestic and foreign literatures of the application of PLGA nanoparticles as an anticancer drug carrier in the field of active and passive targeting were reviewed .Result Because nanomaterials can enhance drug delivery to tumor cells and polylactide-co-glycolide is a biodegradable and biocompatible polyester approved for human use by FDA ,in recent years PLGA becomes a research hotspot .Conclusion Poly(lactide-co-glycolide) nanoparticles used for anticancer agents delivery has a promising prospect .%目的：阐述近年来PLGA 纳米粒作为抗肿瘤药物载体的研究进展。方法归纳国内外最新的文献报道，对PLGA纳米粒作为抗肿瘤药物载体在主动与被动靶向方面的应用研究进展进行综述。结果由于纳米材料可以增强抗肿瘤药物的靶向作用，而PLGA是经FDA认证的具有生物降解性及生物相容性的功能高分子有机聚合物，已经被广泛地应用于抗肿瘤药物的载体研究。结论 PLGA纳米粒作为抗肿瘤药物载体具有广阔的应用前景。