反复呼吸道感染患儿红细胞免疫及T淋巴细胞亚群变化关系的研究

摘要

Objectives　 In order to detect the red cell immunology function and T-lymphocyte subsets of children with recurrent respiratory tract infection(RRTI).Methods　 The red cell immunol complex rosette(RICR) and red cell receptor rosette(RCRR) and CD３、CD4、CD8 T-lymphocyte subsets were assayed for 60 children with RRTI and 20 cases of health control group.Results　 It was compared to show that RICR in children with recurrent respiratory tract infection was higher than that in the control group ,RCRRwas lower than that in the control group,That CD3、CD4 T-lymphocyte of children with RRTI was lower than the control group and CD8 was higher than the control group.There was a negative correlation between RICR and CD4 T-lymphocyte.There was a positive correlation between RCRR and CD4 T-lymphocyte.Conclusions　 There is double dysfunction of red cell immunology and T-lymphocyte subsets in children with RRTI.%目的探讨反复呼吸道感染患儿红细胞免疫和T淋巴细胞亚群变化的关系。方法应用红细胞酵母多糖花环法和APAAP酶联法测定60例反复呼吸道感染患儿和20例正常对照组红细胞免疫复合物花环和C３b受体花环及CD３、CD４、CD８ T淋巴细胞亚群。结果反复呼吸道感染患儿红细胞免疫复合物花环增高，C３b受体花环降低，T淋巴细胞亚群CD３、CD４降低，CD8增高。红细胞免疫复合物花环和CD4存在负相关。红细胞C3b受体花环和CD４存在正相关。结论反复呼吸道感染患儿同时存在T淋巴细胞和红细胞双重免疫功能障碍。