Intracellular sorting pathways of the amyloid precursor protein provide novel neuroprotective strategies

摘要

Alzheimer’s disease(AD)is the most common cause of senile dementia.It is characterized by the formation of plaques mainly composed of the amyloid-beta peptide(Aβ).Diverse lines of evidence support the notion that accumulation of Aβis a primary cause of AD pathogenesis(Huang and Mucke,2012).Amyloid precusor protein(APP)processing is dependent on its subcelluar trafficking pathway:Aβis derived from APP by proteo-