Matrix bound vesicles and miRNA cargoes are bioactive factors within extracellular matrix bioscaffolds

摘要

Injury to central nervous system(CNS)tissues in adult mammals often leads to neuronal loss,scarring,and permanently lost neurologic functions,and this default healing response is increasingly linked to a pro-inflammatory innate immune response.Extracellular matrix(ECM)technology can reduce inflammation,while increasing functional tissue remodeling in various tissues and organs,including the CNS.However,ECM bioscaffold delivery and the rapid ECM