Objective:To evaluate the efficacy of low-dose tacrolimus treatment on patients with refractory gener-alizedmyasthenia gravis (MG).Methods:Twelvecasesofrefractorygeneralized MG were treatedwithlowdose of FK-506. The clinical manifestation, Oosterhuis score, MG-ADL score and drugs usage were evaluated. Results:Oosterhuisscoreswasimproved in9 caseswith regular therapyofFK-506.Five cases could take care of themselves in daily life. Only 1 case was confined to bed because of femoral bone head necrosis, but the muscle strength im-proved significantly. The frequency of hospitalization was reduced in 5 cases. The doses of prednisolone were also reduced in 8 cases, and 1 case with long-term maintenance in low dose. Conclusion:Low-dose tacrolimus was ef-fective andsafe inthe treatmentofrefractorygeneralizedMG.% 目的:探讨小剂量他克莫司用于难治性全身型重症肌无力的疗效。方法:选择12例临床资料完整的难治性全身型重症肌无力患者,采用小剂量他克莫司进行治疗,分析患者的一般情况、Oosterhuis记分、MG-ADL评分、药物用量等。结果:9例坚持用药的患者Oosterhuis记分均明显减少;5例现生活自理,1例因股骨头坏死致行动困难,但肌力明显改善;5例住院次数减少,用药后8例患者使用激素量减低,1例为小剂量长期维持。结论:小剂量他克莫司治疗难治性全身型重症肌无力,可改善日常生活质量,减少激素用量。
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