脑梗死患者高尿酸血症与颈动脉粥样硬化关系的临床研究

摘要

Objective:To investigate the correlation of hyperuricemia (HUA) and carotid atherosclerosis in pa tients with cerebral infarction.Methods:Two hundred and eighty-three patients with cerebral infarction were enrolled,including LAA,CE,and SAA subtypes.The uric acid (UA) level was detected and the mean intima media thickness (IMT) of the common carotid artery (CCA) and bifurcation of the carotid artery were examined by color Doppler ultrasound in all the patients.The relationship between HUA and carotid atherosclerosis were evaluated.Results:The average IMT,average size of plaques and number of plaques of the CCA in the HUA group were higher than those in the normal UA level group (P＜0.05).The hypertriglyceridemia (P=0.024,OR 1.300,95％CI 1.014～1.194),renal failure (P=0.030,OR 1.534,95％CI 1.043～2.581),LAA (P=0.004,OR 2.017,95％CI 1.256～4.018) were the risk factors for HUA in the cerebral infarction patients.Conclusion:There is a close correlation between carotid atherosclerosis and HUA,and HUA may be a risk factor for cerebrovascular trauma.%目的:探讨脑梗死患者中高尿酸血症(HUA)与颈动脉粥样硬化间的关系.方法:选取脑梗死大动脉粥样硬化性卒中(LAA)、心源性脑栓塞(CE)、小动脉闭塞性卒中或腔隙性卒中(SAA)患者283例,检测血清尿酸水平,使用彩色超声评估双侧颈总动脉及颈总动脉分叉处内膜厚度,分析颈动脉粥样硬化与HUA间的关系.结果:HUA组颈总动脉内膜厚度、斑块的数量及大小均高于正常尿酸组(P＜0.05).脑梗死患者中高甘油三血酯症(P=0.024,OR直1.300,95％CI为1.014～1.194)、肾功衰(P=0.030,OR值1.534,95％CI为1.043～2.581)、LAA(P=0.004,OR值2.017,95％CJ为1.256～4.018)为罹患HUA的危险因素.结论:HUA与颈动脉粥样硬化间关系密切,HUA是脑血管损伤的危险因素.