探讨壳寡糖螯合铬(Cos-Cr)的降血糖作用.选择发育相近的健康雄性小鼠10只为正常对照组,糖尿病小鼠30只随机分为糖尿病对照组、壳寡糖组(Cos)和螯合铬组(Cos-Cr),每组各10只,实验期4w,测定小鼠血糖值.壳寡糖螯合铬可以降低糖尿病小鼠血糖,增加体重,增加脾脏指数,明显缓解糖尿病小鼠饥饿和烦渴的症状.肝脏损伤明显减轻.同时观察肝组织病理变化.壳寡糖螯合铬对糖尿病小鼠有降糖,改善糖尿病症状的作用.%To study the effects of chitooligosaccharide-chromium( III ) complex(Cos-Cr)on diabetic mice. Selecting ten male mice as the normal control group. Thirty diabetes mice were randomly divided into 3 groups, diabetes control group (n = 10),Cos group (n = 10), Cos-Cr group (n = 10). The mice were dissected after 4 weeks, determinations of serum glucose concentration. Cos-Cr can significantly decrease fasting blood glucose level, increase body weight as well as index spleen. Symptoms of hunger and thirsty were improved obviously in diabetic mice. Cos-Cr has protective effects on alloxan-induced hepatic injury in mice. Hepatocytes lesion was alleviated markedly. Cos-Cr can decrease blood glucose concentration and improve diabetic symptoms in mice.
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