地佐辛在全麻苏醒期应用的临床观察

摘要

Objective Observation of clinical effect of dezocine for general anesthesia recovery period. Methods Choice of gynecological laparoscopic operation of general anesthesia in 60 cases, were randomly divided into two groups, control group(group A) and dezocine group(group D), 30 cases in each group. Two groups were treated with tracheal intubation general anesthesia, operation end 20min prior to D group intramuscular injection of dezocine 0.1mg/kg, A group was not given any drug. Comparison of two groups of patients recovery time, extubation time, before awakening, extubation, 10min after extubation MAP, HR changes, the two groups were recorded after extubation pain, chills and agitation in the incidence of adverse reactions. Results Recovery time, extubation time, changes of MAP, HR before awakening in the two groups showed no significant difference(P >0.05), and the two group of patient extubation, 10min after extubation MAP, HR changes and postoperative shivering, agitation and pain scores weretatistically significant(P <0.05). Conclusion Before the end of operation 20min intramuscular injection of dezocine can effectively inhibit the extubation period hemodynamic fluctuations, reduce postoperative nausea and vomiting, chills, the incidence of agitation rate, and does not affect the postoperative recovery.%目的：观察地佐辛用于全麻苏醒期的临床效果。方法将全麻妇科腹腔镜手术60例随机分为对照组(A组)和地佐辛组(D组)各30例。两组均采用气管插管静脉麻醉，手术结束前约20min给予D组肌注地佐辛0.1mg/kg，A组不给任何药物。比较两组患者的苏醒时间、拔管时间，苏醒前、拔管时、拔管后10minMAP、HR的变化，记录两组患者拔管后疼痛、寒战及躁动不良反应的发生例数。结果两组苏醒时间、拔管时间、苏醒前MAP、HR的变化无统计学差异(P >0.05)，两组患者拔管时、拔管后10minMAP、HR的变化和术后发生寒战、躁动的例数及镇痛评分有统计学差异(P <0.05)。结论手术结束前20min肌注地佐辛能有效抑制拔管期血流动力学的波动，减少术后恶心呕吐、寒战、躁动的发生率，且不影响术后苏醒。