21例克林霉素注射液致不良反应分析

摘要

Objective To explore the rules and causes of adverse reactions by using Clindamycin Injection. Methods Analysing 21 patients' basic, primary disease, the incidence of adverse reactions who causing adverse drug reactions by Clindamycin Injection. Result 21 cases of Clindamycin injection adverse reactions in patients with women slightly more than men, but there is no statistical significant(P >0.05); 60 years old or more accounted for 17 cases of adverse reactions in patients, under the age of 60 accounted for 4 cases, with statistically significant(P <0.05); 21 patients' primary disease are infectious diseases; adverse reactions occur in 15min-45min accounted for 16 cases, compared to <15min and >45min group, the difference was statistical significant(P <0.05); clinical manifestations of adverse reactions included the skin and appendages (9 cases), systemic reactions(6 cases), cardiovascular system damage(3 cases), respiratory system damage(3 cases). Conclusion Clindamycin injection adverse reactions caused no significant relationship with patients' gender, adverse reactions mostly occurred in patients over the age of 60, the adverse reaction time more appear in 30min after administration, adverse reactions more performance for the damage to the skin and its appendages, in severe cases, there will be anaphylactic shock, chest tightness, shortness of breath and other symptoms with patients.%　　目的探讨使用克林霉素注射液后发生不良反应的特点及规律。方法对本院21例使用克林霉素注射液后出现不良反应的患者的基本情况、原发疾病、不良反应发生情况进行分析。结果克林霉素注射液所致21例不良反应患者女性较男性稍多，但没有统计学差异(P >0.05)；不良反应患者中60岁以上占17例，60岁以下占4例，具有统计学差异(P <0.05)；21例患者原发病均属于感染性疾病；不良反应出现在15-45min者占16例，与<15min组及>45min组相比差异有统计学意义(P <0.05)；不良反应临床表现为皮肤及附件损害(9例)，全身反应(6例)，心血管系统损害(3例)，呼吸系统损害(3例)。结论克林霉素注射液致不良反应与患者性别无明显关系，不良反应多发生在60岁以上患者中，时间多出现在用药后30min左右，多表现为皮肤及附件损害，严重者会出现过敏性休克、胸闷、呼吸困难等症状。