海莲内生真菌Pestalotiopsis clavispora代谢产物研究

摘要

从海莲内生真菌Pestalotiopsis clavispora发酵液乙酸乙酯萃取物中分离得到9个化合物.根据波谱数据,化合物1-9结构分别鉴定为:3β,22β,24-三羟基齐墩果-12-烯,乌苏酸,3-羟基-4-甲氧基苯乙烯,邻苯二甲酸二异丁酯,3,4-二羟基苯乙醇,对羟基苯乙醇,3β-羟基-5α,8α-过氧化麦角甾-6,22-二烯,麦角甾-4,6,8(14),22-四烯-3-酮,胸苷.9个化合物均为首次从该内生真菌中分离得到.%Nine known compounds, 3β,22β,24-trihydroxy-olean-12-ene, ursolic acid, 3-hydroxy-4-methoxystyrene, diisobutyl phthalate, 3,4-dihydroxyphenylethanol, p-tyrosol, 3β-hydroxy-5a,8a-epidioxyergosta-6,22-diene, ergosta-4,6,8(14),22-tetraen-3-one and thymidine, were isolated from the ethyl acetate extraction of fermentation broth of Pestalotiopsis clavispora, an endophyte in the stems of Bruguiera sexangula. The structures of these compounds were elucidated by extensive spectroscopic analysis. These compounds were isolated for the first time from endophytic fungus Pestalotiopsis clavispora.