Paclitaxel (taxol(R)), a member of taxane family, has become a widely used anticancer drug in clinic. The industrial fermentation of taxol by fungi promises an effective way to increase the production and supply of the drug in the market. This review summarizes the latest results of the biodiversity of taxol-producing fungi, the fungal taxonomy, purification and characterization of fungal taxol, and molecular genetics of taxol biosynthesis.%紫杉醇(Taxol(R))是天然抗癌药物,已在临床上广泛使用,市场需求量大,由于生产原料的制约,供需之间存在巨大缺口,价格仍然昂贵.利用真菌发酵生产紫杉醇是解决药源的一条新途径.对产紫杉醇内生真菌的多样性,紫杉醇真菌的采集鉴定、真菌紫杉醇提取和测定的一些经验,紫杉醇真菌分子生物及生物合成代谢研究进展等进行了综述.
展开▼
