This article is aimed to discuss laws of compound medicine application of traditional Chinese medicine (TCM) in the treatment of influenza A (H1N1). Data of 4037 influenza A (H1N1) cases were collected in a multi center cohort study using compound TCM treatment during the influenza A (H1N1) outbreak in Guangzhou from De cember 2009 to April 2010. The laws of TCM compound medicine application were summarized based on syndrome differentiation. The result showed that 156 kinds of Chinese herbs were used. The medicinal effect is for heat-clear ing and detoxifying, relieving cough, phlegm and asthma, wind-cold dispersing, wind-heat dispersing, heat-clearing and fire-purging. It occupies 51.90% in the prescription. There were 28 kinds of TCM medicinals which were com monly used. The channel -tropism involved 12 channels. The main channels were the Lung meridian, Stomach meridian, Heart meridian, and liver meridian. The proportion of these medicinals occupies 78.71%. All medicinals cover seven kinds of tastes. The top three tastes were bitter, sweet and pungent. The proportion of them was 99.57%. The top ten of commonly used TCM medicinals (except for licorice) were campanulaceae, forsythia, honey suckle flower, mulberry leaves, reed rhizome, mint, chrysanthemum, bamboo leaf, arctium, and almonds. The most frequently used prescription in the group of expelling exogenous wind-heat was Yin-Qiao-San. And the prescription of expelling exogenous wind-cold was Jing-Fang-Bai-Du-San. The frequency of using Ma-Xing-Shi-Gan-Tang to remove toxic heat obstruction in the lungs was up to 100%. It is concluded that the efficacy, taste, channel-tropism, and compatibility of TCM medicinals used in the treatment of H1N1 flu were closely related to etiological factor and pathogenesis of Influenza A (H1N1).%目的:探讨治疗甲型H1N1流感中药复方遣药组方的用药规律.方法:收集2009年12月～2010年4月新型甲型H1N1流感暴发期间多中心队列研究过程使用中药复方治疗甲型H1N1流感的4037例病例资料,总结辨证使用中药复方的用药规律.结果:使用中药156种,主要是清热解毒药、止咳化痰平喘药、发散风寒药、发散风热药、清热泻火药,占51.90％；常用中药28味；药物归经涉及12经,主要是肺经、胃经、心经、肝经,共占78.71％；所有药物涉及7种药味,前3位为苦、甘、辛,共占99.57％；常用中药排名前10位是(除甘草外)桔梗、连翘、银花、桑叶、芦根、薄荷、菊花、竹叶、牛蒡子、杏仁；外感风热组银翘散应用频率最高；外感风寒组荆防败毒散应用频率最高；热毒壅肺型麻杏石甘汤应用频率高达100％.结论:甲型H1N1流感所用药物功效、性味、归经和配伍与甲型H1N1流感的病因、病机密切相关.
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