基于中医学“异病同治”理念探究神经精神疾患共病机制

摘要

This study was aimed to investigate the mechanism underlying the neuropsychiatric comorbidity in the process of "stress"-"inflammation"-"comorbidity",from the perspective of traditional Chinese medicine (TCM) basic theory in combination with our previous 20-year findings.Notably,the neural-psychiatric comorbidity between psychiatric disorders,including depression,schizophrenia and anxiety,and systemic diseases,such as ischemic stroke,Alzheimer's disease (AD) and asthma,have something in common in the pathophysiological mechanism.The stress-induced structural and functional changes in the brain,the stress-initiated diversely structural and neurobiological changes in neurocircuitry,and the stress-mediated neurochemical alterations in neurotransmitter are considered to be involved in the common pathophysiological mechanisms in the neural-psychiatric comorbidity,which initiates a cascade of physiological and psychological processes that contributes to the development of various types of neuropsychiatric disorders.Accordingly,it will be of great significance to investigate mechanisms underlying the neuropsychiatric comorbidity in the process of "stress"-"inflammation"-"comorbidity" under the guidance of the basic theory of "treating disease from the root" and "same treatment for different diseases" in TCM.%基于中医学疾病观与治疗观,结合本课题组20年研究工作,从“应激”-“炎性”-“共病”这一关键途径出发,探究神经-精神系统日趋明显,揭示共病性病理机制.抑郁症、精神分裂症、焦虑症等精神疾患与缺血性中风、阿尔兹海默病、哮喘等存在明显的病理、生理学机制重叠:涉及共同的脑区结构、激活共同的神经生物学环路、影响共同的神经化学物质、获得了确切的疗效.因此,“治病求本”和“异病同治”效应指向的“神经-精神系统疾患共病”将是我们今后深入探究的主题.