Objective To study the efficacy and prognostic factors for sudden sensorineural hearing loss with the treat-ment of mouse nerve growth factor and other medication. Methods 134 sudden sensorineural hearing loss ears were reviewed retrospectively in our department. They were treated by mouse nerve growth factor, lipo-prostaglandin E1, ginaton and methyl-prednisolone, the therapeutic effect were evaluated by pure tone audiometry. Results The total effective rate was 82.1%. Age, the time of diagnosis and therapy, the type of audiogram and degree of hearing loss would be connected with the prognosis (P<0.05 or P<0.01). Conclusion The curative effect of patients whose age is under 50 have short duration and mild degree of deafness is better than those whose age is over 50, have long duration and severe degree of deafness. The types in low tone frequencies show the best curative effect, followed by the types in all frequencies, the types in high tone frequencies and the to-tal deafness have poor curative effect.%目的：研究鼠神经生长因子等药物治疗突发性耳聋的疗效及其预后影响因素。方法回顾性分析我科收住的134耳突发性耳聋患者，给予鼠神经生长因子、前列腺素E1脂微球载体、银杏叶提取物、甲强龙静脉输液治疗，纯音听阈检查判定疗效。结果药物治疗的总有效率为82.1%。年龄、发病至就诊时间、听力曲线类型及听阈损失程度与疾病的预后相关（P＜0.05或P＜0.01）。结论年龄＜50岁、病程短、听力损失程度轻的患者比年龄≥50岁、病程长、听力损失程度重的患者疗效好。低频听力下降型治疗效果最好，全频听力下降型次之，高频听力下降型和全聋治疗效果差。
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