Objective It is to observe the clinical efficacy of point selection by midday-midnight combined with traditional Chinese medicine in the treatment of premenstrual syndrome (PMS) and its effect on neuroendocrine system and sleep quality. Methods Sixty patients with PMS were randomly divided into observation group (30 cases) and control group (30 cases). The control group was treated with western medicine. The observation group was given acupuncture therapy of midnight-noon ebb-flow and self-made traditional Chinese medicine on the basis of the control group. Both groups were treated for 3 menstrual cycle. The clinical efficacy was observed, and the changes of TCM syndrome scores, neuroendocrine system and sleep quality before and after treatment were recorded. Results The total effective rate of the observation group was higher than that of the control group (P＜0.05). After treatment, the scores of anxiety and irritability, breast pain, headache, insomnia and dreams, decreased libido, abdominal pain, stomach cramps, inattention, and total scores were significantly decreased in the two groups (P＜0.05), the scores of the first 5 items and total scores in the observation group were lower than those in the control group (P＜0.05). The levels of progesterone (P) and estradiol (E2) in the follicular and luteal phase of the two groups were significantly increased after treatment, and the level of prolactin (PRL) was decreased (P＜0.05), the improvements of these indexes in the follicular and luteal phase in the observation group were better than those in the control group (P＜0.05). The scores of sleep quality, sleep latency, sleep efficiency, daytime function, sleep time, sleep dysfunction, and total score in PSQI after treatment were significantly decreased in the two groups (P＜0.05), the scores of the first 4 items and total scores in the observation group were lower than those in the control group (P＜0.05). Conclusion The clinical effect of point selection by midday-midnight combined with traditional Chinese medicine which can not only reduce the clinical symptoms of patients, but also regulate the secretion of sex hormones and improve the quality of sleep is significant in the treatment of PMS, it is worthy of clinical recommendation.%目的 观察子午流注开穴法联合中药治疗经前期综合征(PMS)的临床疗效及对神经内分泌系统和睡眠质量的影响.方法 将60例PMS患者随机分为观察组30例及对照组30例,对照组给予西医治疗,观察组在对照组治疗基础上给予子午流注开穴法+自拟中药治疗,2组均治疗3个月经周期.观察临床疗效,并记录2组治疗前后中医证候积分、神经内分泌系统和睡眠质量的变化情况.结果 观察组治疗总有效率明显高于对照组(P＜0.05);2组治疗后烦躁易怒、乳房胀痛、头痛、失眠多梦、性欲降低、小腹胀痛、胃脘胀痛、注意力不集中、总积分均显著降低(P均＜0.05),观察组治疗后前5项及总积分均明显低于对照组(P均＜0.05);2组治疗后卵泡期和黄体期血清性激素指标孕激素(P)、雌二醇(E2)水平均显著升高(P均＜0.05),泌乳素(PRL)水平显著降低(P均＜0.05),且观察组治疗后的卵泡期和黄体期以上指标改善情况均优于对照组(P均＜0.05).2组治疗后匹斯堡睡眠质量指数(PSQI)中睡眠质量、入睡时间、睡眠效率、日间功能、睡眠时间、睡眠障碍、总分均显著降低(P均＜0.05),观察组前4项和总分均显著低于对照组(P均＜0.05).结论 子午流注开穴法联合中药治疗PMS的临床疗效显著,不仅能够减轻患者临床症状,还能够调节机体性激素分泌,改善睡眠质量,值得临床推荐.
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