Objective It is to approach the influence of treatment condition of maternal syphilis on neonatal syphilis serology, follow up the serological results and heighten the realization on syphilis serology. Methods The characteristics of syphilis serology and follow up of partal neonates of 86 syphilis females ( 23 cases was treated before pregnancy, 26 cases was treated during pregnancy and 37 cases was untreated ) from May 2006 to May 2009 were analyzed retrospectively. Results In treated before pregnancy group, all neonates were RPR negative at birth, 21 neonates were TPPA positive and the negative rate was 100％ at 6 months. In treated during pregnancy group, 5 neonates were RPR positive and the negative rate was 100％ at 6months, 25 neonates were TPPA positive and the negative rates were 80％ and 92％ at 6 and 9 months respectively. In untreated group, 35 neonates were RPR positive and 36 neonates were TPPA positive and all of them accepted treatment. The negative rates of RPR were 74％ , 83％ , 91％, 100％ and that of TPPA were 3％ , 8％ , 11％ 14％ at 6, 9, 12, 15 months respectively. The growth and development of most children were normal or near normal. Conclusion Early diagnosis and treatment of maternal syphilis can lower the incidence of congenital syphilis. Through the follow up of syphilis serology , the realization on syphilis serology is heightened and the assistance is supplied about clinical diagnosis and treatment of congenital syphilis.%目的 探讨母亲梅毒治疗情况对新生儿梅毒血清学的影响,并对血清学结果进行随访,提高对梅毒血清学的认识.方法 回顾分析2006年5月-2009年5月86例女性梅毒患者(孕前治疗23例、孕期治疗26例、未治37例)分娩新生儿的梅毒血清学及其随访的特点.结果 孕前治疗组中新生儿出生时RPR均阴性,TPPA阳性21例,TPPA 6个月阴转率100%.孕期治疗组中新生儿出生时RPR阳性5例,RPR 6个月阴转率100%,TPPA阳性25例,TPPA 6,9个月阴转率分别为80%,92%.未治疗组中新生儿出生时RPR阳性35例、TPPA阳性36例,均接受治疗.RPR 6,9,12,15个月阴转率分别为74%,83%,91%,100%.TPPA 6,9,12,15个月阴转率分别为3%,8%,11%,14%.大部分患儿生长发育正常或接近正常.结论 早期诊断、早期治疗母亲梅毒,可降低先天性梅毒的发生率.通过对梅毒血清学的随访,提高了对梅毒血清学的认识,可为临床诊断及治疗先天性梅毒提供帮助.
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