辛芩颗粒联合氯雷他定治疗过敏性鼻炎临床研究

摘要

目的：观察辛芩颗粒联合氯雷他定治疗过敏性鼻炎的疗效及对血白细胞介素－4（IL－4）、IL－10和免疫球蛋白E（IgE）水平的影响。方法将70例过敏性鼻炎患者随机分为观察组和对照组，每组35例。对照组给予氯雷他定治疗，观察组在对照组治疗的基础上给予辛芩颗粒治疗。观察2组临床疗效、不良反应和复发率，记录治疗前后喷嚏、流涕、鼻堵和鼻痒评分及血IL －4， IL－10和IgE水平。结果观察组总有效率明显优于对照组（ P ＜0．05），而复发率明显低于对照组（P＜0．05），2组不良反应发生率比较差异无统计学意义（P＞0．05）。2组治疗后喷嚏、流涕、鼻堵和鼻痒评分及血IgE和IL－4水平均较治疗前明显降低（P均＜0．05），血IL－10水平均较治疗前明显升高（P均＜0．05），且观察组变化较对照组更为明显（P均＜0．05）。结论辛芩颗粒联合氯雷他定治疗过敏性鼻炎疗效确切，其机制可能为通过降低血IL－4、IgE水平和升高IL－10水平从而改善过敏性鼻炎的症状。%Objective It is to observe the effect of Xinqin particles combined with loratadine in allergic rhinitis, and its in-fluence on the levels of IL-4, IL-10 and IgE.Methods 70 patients with allergic rhinitis were randomly divided into obser-vation group and control group with 35 cases in each group.The patients were treated with loratadine in the control group, and with loratadine plus Xinqin particle in the observation group.The clinical curative effect, adverse reaction and recurrence rate were observed after treatment.The levels of IL-4, IL-10 and IgE, and the scores of signs and symptoms before and after treatment were observed in two groups.Results The total effective rate of observation group was significantly better than that of control group (P<0.05), and the recurrence rate of observation was markedly lower than that of control group (P<0.05), there was no significant difference in adverse reaction between the two groups (P>0.05).After treatment, the scores of snee-zing, runny nose, nasal blockage and nasal itching, and the levels of IgE and IL-4 were significantly lower in two groups than before treatment (all P<0.05), and the levels of IL-10 were increased in two groups (P<0.05), and the observation group was more significant than the control group (all P<0.05).Conclusion The effect of Xinqin particles combined with lo-ratadine in treating allergic rhinitis is exact, their mechanism maybe reduce the levels of IgE, IL-4 and increase the level of IL-10, so as to improve the symptoms of allergic rhinitis.