皮下包埋两性霉素B对兔真菌性皮肤病治疗效果研究

摘要

Rabbit fungal skin disease is a kind of highly contagious and contact skin diseases between human beings and livestock. Positive test to select a weight similar to guitar rabbit farm breeding suspected rabbit fungal skin disease in clin-ical symptoms, examination, diagnosis rabbits infected with fungal skin disease Par-asitology. Divided into three groups(n=10), sub-cage artificial feeding of 30 days, other things being equal. Group Ⅰfor the control group, not administration. 5 mg of Amphotericin B subcutaneous injection in Group II,group of three subcutaneous injec-tion of 10 mg of Amphotericin B. Measure weight and mites in check. Prior to adminis-tration and 30 days after dosing, weighing 10 days 20 days 30 days before drug admin-istration and mites inspection. The experimental group weight gain all higher than the other groups, have a certain effect of Amphotericin B for the treatment of rab-bit mites echinococcosis. And 5mg and 10mg dose of the treatment of rabbit fungal skin disease effect was significantly higher than groupⅠ. The results show that the effect of amphotericin B in the content of 5 mg to the treatment of fungal skin diseases of Rex Rabbit is significant. The subcutaneous embedding of mode of admin-istration can effectively extend the effective time of amphotericin B.%　　兔真菌性皮肤病是一类传染性极强的人畜共患接触性皮肤病。试验选取体重相近，已感染真菌性皮肤病的吉戎兔15只，分为3组，每组5只，试验组Ⅰ为对照组，注射生理盐水，组II和组Ⅲ皮下分别包埋5 mg和10 mg的两性霉素颗粒剂。给药前和给药后第10天、第20天和第30天分别称重，并观察测定兔皮毛生长及秃斑恢复情况。结果表明，试验组兔增重均高于对照组，差异显著（P＜0.05），试验末期组II和组Ⅲ秃斑恢复分别达95%和90%。因此，采用皮下包埋的给药方式有效地延长了两性霉素B的药效时间，可有效治愈兔真菌性皮肤病。