Micellar system containing thermo reversible for subcutaneous and topical amphotericin B in the treatment of visceral leishmaniasis and integumentary

摘要

Micellar system containing thermo reversible for subcutaneous and topical amphotericin B in the treatment of visceral leishmaniasis and tegument air. Micellar system term reversible (SM) containing amphotericin B (anb) is a formulation based on the copolymer poloxamer 407 in which triblock The anb is solubilizada / dispersed in its monomeric form.SM - anb in gel provides slow release of anb in the form of micelles / particles with average size of approximately 130 nm. The stability of sol and gel state anb in SM anb is more than 95% after 360 days, when vitamin E is added to the system.SM - anb, compared with the formulations of anb described in the state of the art, also provides the differential can be applied topically on skin lesions and mucosal ulcerations, and joined in the area where it is applied for a long period.