2型糖尿病肾病与视黄醇结合蛋白4的相关性研究

摘要

目的：探讨视黄醇结合蛋白4对于2型糖尿病肾病的临床检测意义。方法随机选择2013年11月～2014年3月来医院诊治的2型糖尿病合并肾病患者68例为研究组，同时随机抽取同期体检健康者68例为对照A组，随机抽取68例2型糖尿病无肾病者为对照B组。测量研究组与对照组的体质指数、血尿视黄醇结合蛋白4以及胰岛素水平。结果研究组的视黄醇结合蛋白4高于对照组，而且视黄醇结合蛋白4与患者体质指数、胰岛素水平呈现相关性。结论视黄醇结合蛋白4检测对于糖尿病肾病早期检测具有重要的意义，可以为早期糖尿病肾病的诊断提供参考依据。%Objective To explore the clinical significance of RBP 4 for type 2 diabetic nephropathy.Methods Ran-domly selected 68 cases of Type 2 diabetic nephropathy that visited our hospital between November 2013 and February 2014 were selected as research group;68 cases that received health examination during the same period were selected as control group A; and 68 cases of Type 2 diabetes without kidney disease were selected as control group B.BMI, RBP 4 and fasting insulin level were measured and compared in different groups.Results The level of BP4 in research group was higher than that in the control group, and BMI and fasting insulin level in research group were associated with the level of BP4.Conclu-sion RBP4 could be used for assistant diagnosis of type 2 diabetic nephropathy , and it has clinical significance for early de-tection of diabetic nephropathy.