目的：探讨慢性心力衰竭并肾功能不全患者外周血同型半胱氨酸（ homocystein，Hcy）和中性粒细胞明胶酶相关脂质运载蛋白（neutrophil gelatinase associated lipocalin，NGAL）的表达及两者的相关性研究。方法选取2013年6月～2014年6月入住南方医科大学北滘医院心血管内科的慢性心力衰竭患者58例，其中合并肾功能不全患者28例，未合并肾功能不全患者30例。心脏超声检测左室射血分数（left ventricular ejection fraction，LVEF），检测外周血BNP、血肌酐、Hcy、以及NGAL的表达。结果与慢性心力衰竭患者相比，外周血Hcy浓度和NGAL水平在慢性心力衰竭合并肾功能不全患者中升高（ p＜0．05）；相关性分析显示所有入选患者外周血中 Hcy 浓度与 NGAL水平呈正相关；Hcy 浓度与 NGAL水平分别与BNP浓度、血肌酐水平呈正相关（p＜0．05），与LVEF呈负相关（p＜0．05）。结论外周血 Hcy和 NGAL水平可反映慢性心力衰竭并肾功能不全患者的发生发展。%Objective To investigate the levels of homocysteinin and neutrophil gelatinase associated lipocalin and its rela-tionship in patients with chronic heart failure combined insufficient renal function .Methods 58 patients with chronic heart failure were enrolled in from June 2013 to June 2014 in Beijiao hospital affiliated Southern medical university .Thereinto, according to pa-tient’s condition, 28 patients were chronic heart failure concurrence insufficient renal function, 30 patients were chronic heart failure. Left ventricular ejection fraction were determined by cardiac ultrasound , the levels of serum BNP, Hcy, NGAL and creatine were de-termined.Results Compared with chronic heart failure patients,the levels of Hcy and NGAL were increased in patients with chronic heart failure concurrence insufficient renal function (p<0.05).Correlation analysis showed that the levels of Hcy is positively corre-lated with the levels of NGAL (p<0.05);the levels of Hcy and NGAL were positively correlated with BNP and creatine (p<0.05), but negatively correlated with LVEF (p<0.05), respectively.Conclusion Circulating levels of Hcy and NGAL can reflect the de-velopment of chronic heart failure concurrence insufficient renal function .
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