不同浓度高渗盐水对脑水肿患者血生化及渗透压的影响

摘要

Objective To explore the effect of different concentrations of hypertonic saline for cerebral ede -ma on blood biochemical and osmotic pressure .Methods 60 cases were randomly divided into the 3% HS group, 7.5%HS group and the mannitol group .The patients were randomly assigned to infusion of 3% HS, 7.5% HS or 20%mannitol (all 2 mL/kg).Blood biochemical and osmotic pressure on patients were measured before and after the treatment among groups .Results Serum Na +, Cl -and osmotic pressure were significantly higher at 2 hours and 22 hours of reperfusion than at baseline (p<0.05) in the 7.5% HS group and the mannitol group .The difference were significant on serum Na +, Cl-and osmotic pressure at 2 hours and 22 hours of reperfusion in the 7.5% HS group and the mannitol group than in the 3% HS group(p<0.05).Conclusion 3% hypertonic saline had less effects on blood biochemical and osmotic pressure than other groups for patients of cerebral edema .It is worthy of popularization and application .%目的：探讨不同浓度高渗盐水（ Hypertonic Saline ，HS）对脑水肿患者血生化及渗透压的影响。方法将60例入选患者随机分为3％ HS组、7.5％ HS组和甘露醇组。3组分别注入3％ HS、7.5％ HS和20％甘露醇，均为2 mL／kg。比较各组患者治疗前后血生化及渗透压的变化。结果7.5％HS组和20％甘露醇组治疗后2 h及22 h的血钠、血氯浓度及血浆晶体渗透压较治疗前明显增高（ p＜0.05）。与3％ HS组比较，7.5％HS组和20％甘露醇组治疗后2 h及22 h的血钠、血氯浓度及血浆晶体渗透压明显增高（ p＜0.05）。结论3％HS对血生化及晶体渗透压的影响更小，更适用于脑水肿患者的治疗，值得在临床上推广应用。