抗 CCP抗体检测在类风湿关节炎诊断中的临床意义

摘要

目的：探讨检测抗环瓜氨酸多肽（ CCP ）水平在类风湿关节炎诊断中的临床应用价值。方法选取类风湿关节炎患者132例，其他类别结缔组织疾病患者42例以及同期接受体检的健康人群40例为研究对象，收集患者基本临床资料，检测三组患者血清中抗CCP抗体滴度进行检测，并对类风湿关节炎诊断过程中抗CCP 抗体的特异度进行计算。结果血清中抗 CCP 抗体对类风湿性关节炎诊断具有很高的特异性，并与类风湿关节炎患者的临床症状相关，抗CCP抗体与C反应蛋白联合检测时可提高诊断的特异性，差异有统计学意义（p＜0．05）。结论抗CCP抗体诊断类风湿关节炎具有较高的特异性，其特异性高于类风湿因子（ RF），抗CCP抗体、RF两者联合检测可提高诊断类风湿关节炎的特异性，抗CCP抗体与临床症状程度相关。%Objective To investigate the clinical application value of Anti -CCP antibody ( CCP) levels in patients with in rheumatoid arthritis ( RA) .Methods 132 patients with rheumatoid arthritis , 42 patients of other categories of connective tissue dis-ease, 40 health cases were collected as the research object.The anti-CCP antibody titers were detected in sera of three patients, and the anti CCP antibody in rheumatoid arthritis in the diagnostic process was calculated .Anti -CCP antibody titers were detected in three group patients, and the specific of anti CCP antibody in diagnosis of rheumatoid arthritis was counted .Results Anti-CCP an-tibody has high specificity for the diagnosis of rheumatoid arthritis , and was correlated with clinical symptoms in patients with rheuma-toid arthritis.Combination detection of anti -CCP antibody and C reaction protein can improve the diagnostic specificity , and the difference was statistically significant (p<0.05).Conclusion The specificity of anti-CCP antibody in diagnosis of rheumatoid ar-thritis is higher and its specificity is higher than that of RF .The combined detection of anti -CCP antibody and RF both can improve the diagnostic specificity of rheumatoid arthritis , and anti-CCP antibodies are related with the degree of clinical symptoms .