新辅助化疗对三阴性乳腺癌患者 Ki67的影响

摘要

Objective To discuss the influence of neoadjuvant chemotherapy for Triple Negative Breast Cancer(TNBC) in patients with Ki67 nuclear antigens.Methods 136 patients with TNBC were selected from June 2012 to March 2014 in our Hospitals, and on the basis, immunohistochemical method was used to detect all patients Ki67 expression in breast cancer tissue .The patients were divided into positive group and negative group before chem -otherapy, and on the basis of Ki67 expression changes after chemotherapy and they were divided into yang to yin (A) group, yin to yang(B) group, Yang invariant(C) group and Yin invariant (D) group.Followed up for 5 years, all patients of chemotherapy efficacy and survival were analysed .Results Before chemotherapy, positive group chemo-therapy curative effect was better than negative group , and the difference was statistically significant (p <0.05); After chemotherapy, in the aspect of effect, A group >C group >D group >Bgroup(p <0.05); After chemotherapy, in the aspect of curative effect, A group >C group >D group >Bgroup(p <0.05).Conclusion Neoadjuvant chemo-therapy can change the patients with TNBC cancer Ki 67 positive expression, and it possible to improve the prognosis of patients survival, which is worth for further clinical research .%目的：探讨新辅助化疗对三阴性乳腺癌（Triple Negative Breast Cancer，TNBC）患者核抗原Ki67的影响。方法选取2012年6月～2014年3月期间我院新辅助化疗治疗的 TNBC 患者136例，依据并采用免疫组化法检测所有患者乳腺癌组织中 Ki67表达情况，化疗前分为阳性组和阴性组，化疗后依据 Ki67表达改变情况阳转阴（A）组、阴转阳（B）组、阳不变（C）组和阴不变（D）组，随访5年，统计分析所有患者化疗疗效和生存情况。结果化疗前，阳性组患者化疗疗效明显优于阴性组，差异有统计学意义（p ＜0．05）；化疗后，在疗效方面，A 组＞C 组＞D 组＞B 组，差异有统计学意义（p ＜0．05）；在5年内生存率方面，A 组＞C 组＞D 组＞B 组，差异有统计学意义（p ＜0．05）。结论新辅助化疗可致使 TNBC 癌患者 Ki67的表达发生转变，有可能改善患者生存预后，值得临床作进一步研究。