不同剂量氨基酸在早期静脉营养中对早产儿重要血生化指标的影响

摘要

Objective The effects of different doses of amino acids on the important blood bio-chemical parameters of premature infants in early parenteral nutrition were discussed.Methods In March 2013 ~ 2014 June were born within 24 hours of admission, birth weight of 1000 ~ 2000g premature 86 cases were randomly divided into three groups, were early intravenous injection of different doses of amino acid, low dose group(EL)1g/kg·d) and daily increase of 1.0g/kg, the dada 3.5g/(kg·d), middle dose group (EM)2g/(kg·d) and daily increase of 1g/kg and the maximum 3.7g/(kg·d), the high dosage group (EH) 3g/(kg·d), the dada of 4g/(kg·d) and conventional other par-enteral nutrition and enteral nutrition support.Results The three groups of preterm infants gener-ally similar, important blood biochemical indexes, three groups of BUN in the 7d differences have were statistically significant (P<0.05), high dose group too of elevation of bun was significantly more; creatinine, pH, bicarbonate, bilirubin and complications were no were statistically significant (P>0.05).Conclusions The 24h in premature infants after intravenous administration of amino acids, 3g/kg·d), the peak value of 4g/kg.d) had an elevated BUN, which increased in the range of tolerance.%目的 通过不同剂量氨基酸在早产儿早期静脉营养中的应用,探讨不同剂量氨基酸在早期静脉营养中对早产儿重要血生化指标的影响. 方法 将2013年3月~2014年6月收治的出生后24h内入院,出生体重1000~2000g的早产儿86例随机分成三组,分别早期静脉应用不同剂量氨基酸,低剂量组(EL)1g/kg·d),每天增加1.0g/kg,最大达3.5g/(kg·d);中剂量组(EM)2g/(kg·d),每天增加1g/kg,最大达3.7g/(kg·d),高剂量组(EH)3g/(kg·d),最大达4g/(kg· d),同时进行常规的其他静脉营养及肠内营养支持.结果 三组早产儿一般情况相似,重要血生化指标的比较,三组BUN在生后第7d差异有统计学意义,P<0.05,高剂量组一过性BUN升高明显多见;肌酐、pH值、碳酸氢盐、胆红素及并发症上差异无统计学意义,P>0.05. 结论 早产儿在生后24h内静脉应用氨基酸,3g/(kg·d),峰值达4g/(kg·d)有一过性BUN升高,这种升高在可耐受范围内.