SIRT1在血管相关性疾病中的研究进展

摘要

沉默信息调节因子2相关酶类1（ silent mating type information regulation 2 homolog-1，SIRT1）是一种依赖于烟酰胺腺嘌呤二核苷酸（ nicotinamide-adenine dinucleotide， NAD）的去乙酰化酶，其可对组蛋白和非组蛋白发挥去乙酰化作用从而调节能量代谢、细胞衰老及凋亡等众多生命过程。在多种血管相关性疾病中，SIRT1通过对相关因子去乙酰化增加细胞能量供应、减少细胞凋亡、减轻炎症反应、抵抗氧化应激、改善血管内皮细胞功能，从而在血管相关性疾病中发挥重要作用。该文旨在对SIRT1在缺血性脑卒中、动脉粥样硬化及肿瘤这3种常见血管相关性疾病中的作用的研究进展及相应的信号通路进行综述。%Silent mating type information regulation 2 homolog-1 ( SIRT1 ) is a nicotinamide adenine dinucleotide ( NAD)-dependent deacetylase, which can deacetylate histone and non-histone proteins and is involved in many life proces-ses, such as energy metabolism, cell senescence and apoptosis.SIRT1 can enhance the cellular energy supply, inhibit cell apoptosis, alleviate inflammation, enhance the resistance of oxidative stress and improve the function of endothelial cells by deacetylating relevant factors in many vascular-related diseases.This article summarizes the current research progress in the function and signal pathway of SIRT1 in ischemic stroke, atherosclerosis and tumors.