目的：分析初诊非小细胞肺癌（NSCLC）患者血清C⁃反应蛋白（CRP）、血清白蛋白（Alb）水平与临床病理特征及患者总生存期的联系，探讨其在NSCLC患者预后转归的临床意义。方法回顾性分析2011年1月－2013年1月医院收治的105例NSCLC患者的临床资料，根据患者术前外周血CRP和Alb中位值，分别分为高值组和低值组，分析CRP、Alb水平高低与临床病理特征的关系，根据随访生存情况，采用Kaplan⁃Meier法单因素、Cox比例风险回归模型多因素分析术前CRP、Alb等因素对NSCLC患者总生存期的影响。结果治疗前NSCLC患者血清CRP的水平为（18．14±10．75）mg／L，Alb值为（35．32±12．83） g／L。 Alb低值组与高龄、淋巴结转移、较晚的临床分期相关，而CRP高值组与淋巴结转移、较晚的临床分期相关，具有统计学意义（ P＜0．05）。单因素分析显示高CRP和低Alb水平与较差的总生存期有关，多因素生存分析显示淋巴结转移，较晚的临床分期和高CRP值是影响NSCLC患者生存预后的独立危险因素。结论 CRP和Alb两项指标对肺癌的诊断、预后判断和疗效监测具有重要应用价值，是NSCLC预后潜在的生物标志物。%Objective To analyze the correlation of serum C⁃reactive protein (CRP), serum albumin (Alb) levels and clini⁃cal pathological features and clinical overall survival in newly diagnosed non⁃small cell lung cancer ( NSCLC) . To investigate the prog⁃nostic evaluation of CRP and Alb in NSCLC. Methods Clinical data of 105 newly diagnosed patients with NSCLC in our department were analyzed retrospectively. They were divided into two groups according to the levels of CRP and Alb. Clinicopathological features and levels of CRP and Alb were compared. In order to determine their prognostic value, overall survival ( OS) was evaluated using the Kaplan⁃Meier method, and multivariate analysis was performed using the Cox proportional hazard analysis. Results The levels of CRP and Alb in newly diagnosed patients with NSCLC were (18.14±10.75)mg/L and (35.32±12.83)g/L respectively. The low Alb group and the high CRP group were related to old age, tumor lymph node metastasis and late clinical stage significantly. Univariate Kaplan⁃Meier analysis revealed a significant correlation between low Alb/high CRP level and poor overall survival. Furthermore, high level of CRP was an independent marker for poor clinical outcome as tumor lymph node metastasis and late clinical stage concerning the multi⁃variate analysis of NSCLC patients. Conclusion The two indicators of CRP and Alb have important value in diagnosis, prognosis and therapeutic of NSCLC and could be the potential biomarkers in prognosis of lung cancer.
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