不同病因慢性肝病患者肝组织中IL-10的表达及意义

摘要

Objective To investigate the expression of interleukin⁃10 ( IL⁃10) in the liver tissues of patients with chronic liv⁃er diseases ( CLD) and determine its association with liver inflammation and liver fibrosis. Methods A total of 93 patients with differ⁃ent types of CLD were enrolled in our study. Twenty⁃three normal liver tissues were included as control. The expression of IL⁃10 was de⁃termined by immunohistochemistry in the formalin⁃fixed, paraffin⁃embedded liver tissues of CLD patients and healthy controls. Results The expression of IL⁃10 was significantly increased in both hepatic lobule and portal area of liver tissues of CLD patients with differ⁃ent etiologies as compared with normal controls ( P<0.01) . CLD patients with high inflammation grades ( G) had higher IL⁃10 expres⁃sion in hepatic lobule and portal area of liver tissues compared to those with lower grades. Significantly higher IL⁃10 expression was found in hepatic lobule and portal area of liver tissues of CLD patients with high fibrotic stages ( S) compared to those with lower stages. Conclusion IL⁃10 may play a pathological role in chronic liver inflammation and fibrosis in CLD.%目的：探讨不同病因的慢性肝病（ CLD）患者肝组织中白细胞介素⁃10（ IL⁃10）的表达及其与肝组织炎症和纤维化的关系。方法收集93例CLD患者及23例正常对照肝组织石蜡标本，免疫组织化学方法检测肝组织中IL⁃10的表达。结果不同病因的CLD患者肝组织中肝小叶及汇管区IL⁃10的表达均较正常对照明显增高（ P＜0．01）。随着肝脏炎症分级（ G）的增高，CLD患者肝组织内肝小叶及汇管区IL⁃10的表达逐渐增强，差异有统计学意义。随着肝脏纤维化程度分期（ S）的增高，CLD患者肝组织内肝小叶及汇管区IL⁃10的表达亦逐渐增高，差异有统计学意义。结论 IL⁃10可能参与CLD患者肝脏的炎症和纤维化的发生。