S100B蛋白在围产医学中的研究进展

摘要

The fundamental diagnostic procedures of perinatal brain injury determined by domestic and foreign scholars are based on the clinical manifestations, cerebral ultrasound, dynamic electroencephalogram monitoring, cerebrospinal lfuid examination, cerebral CT, MRI and doppler ultrasound. However, these methods mentioned above have some shortcomings, such as inconvenience, complexity, poor dynamic monitoring, high medical cost, late for ifnding the brain injury, et.al, which often result in slow diagnosis and treatment. However, the S100B protein coming from the brain itself, as the direct predictive factors of cell injury in nervous system, have some advantages, such as high sensitivity, easy operation, good reproducibility, easy dynamic monitoring, et.al. Furthermore, it can quantitatively observe the brain injury. The paper introduces the biological characteristics, detection methods of S100B protein and the recent developments of its applications in perinatal medicine.%国内外学者确定围产儿脑损伤的基本诊断步骤主要是建立在临床表现、大脑超声、动态脑电图监测、脑脊液检查、脑部CT、MRI、及多普勒的基础之上，但这些方法具有不便利性、复杂性、动态监测性差、医疗费用高、发现脑损伤时间较晚等缺点，这就导致临床上不能及早诊断及采取治疗措施。而脑自身成份S100B作为神经系统细胞损伤的直接预测因子，具有敏感性高、便于操作、重复性好、可以进行动态监测等优点，同时还可以对脑损伤程度进行定量观察。现就S100B蛋白的生物学特性、检测及其在围产医学中的应用进行综述。