小型猪慢性心力衰竭模型研究进展

摘要

慢性心力衰竭是一种复杂的心血管综合征，建立合适的慢性心力衰竭动物模型是研究慢性心力衰竭发病机制及相关药物治疗的关键。小型猪因其在病理生理、解剖结构等方面更接近人类，故建立小型猪慢性心力衰竭模型已成为研究热点。目前较成熟的小型猪慢性心力衰竭模型制备方法主要有心肌梗死型、前负荷过载型、后负荷过载型、药源型和心动过速型等。%Chronic heart failure(CHF) is a complex cardiovascular syndrome.The establishment of an appropri⁃ate animal model of CHF is crucial for the study of pathogenesis and pharmacotherapy in CHF.Porcine models of chronic heart failure have became imperative because minipig is closer to human in physiopathology and anatomy. In recent years,the commonly used methods of minipig models of CHF are myocardial infarction,volume over⁃load,pressure overload,drug⁃induced and ventricular rapid pacing.