碱性成纤维细胞生长因子和骨保护素的生物学作用研究进展

摘要

Basic fibroblast growth factor( bFGF)could promote the proliferation of osteoblasts,while osteo-protegerin( OPG )is a kind of inhibitory factor of osteoclasts, both of which are important to bone regeneration and reconstruction. Recently more and more researches demonstrate that,bFGF and OPG are expressed not only in all body tissues and organs,but also in periodontal tissues. In addition, the repair of alveolar bone defects could be enhanced by the combined application of OPG and bFGF, indicated by experiment results. Here is to make a review on the biological characteristics and effects of bFGF and OPG.%碱性成纤维细胞生长因子(bFGF)能够促进成骨细胞增殖,而骨保护素(OPG)是一种破骨细胞抑制因子,两者对于骨的再生与修复具有重要作用.近年来很多研究表明bFGF与OPG不仅在人体各组织器官中有大量表达,而且在口腔牙周组织也同样有所表达,并且有实验结果表明,OPG和bFGF的联合应用可促进犬牙槽骨缺损修复.现就bFGF和OPG的生物学特性及其作用予以综述.