神经干细胞移植治疗阿尔茨海默病研究现状

摘要

Transplantation of neural stem cells( N SCs )in the treatment of Alzheimer disease( AD )is a promising method,with a broad research and application prospect.Therapy of AD with NSCs is aimed at repairing and replacing the damaged nerve cells, and the reconstruction of the damaged cells.Main methods include:endogenous pathway, which is induced by endogenous neural stem cell proliferation and differentiation ( self-repair ), making the damaged central nervous system repair itself; exogenous way, a direct replacement of the damaged/missing tissue or implantation of genetically engineered cells,which can secrete cytokines to promote stem cell proliferation and survival.The exact effect of NSCs transplantation as the treatment of human AD is still lacking sufficient evidence, and how to evaluate its role in the human neurological function recovery is still under study.%神经干细胞(NSCs)治疗阿尔茨海默病(AD)可以修复和替代受损神经细胞,并重建细胞环路和功能.主要方法包括内源性途径,即诱导内源性NSCs增殖与分化,使损伤的中枢神经系统进行自我修复;外源性途径,即直接替代缺损组织或植入基因工程细胞,这一类细胞能分泌促进干细胞增殖与存活的因子.目前,用NSCs移植治疗人类AD的确切疗效还缺乏足够的证据,如何评价其对人类神经功能恢复所起的作用尚在研究中.