磷酸二酯酶与疾病相关的药理学研究进展

摘要

Cyclic nucleotide phosphodiesterases( PDEs ), which are distributed in mammalian tissues,play an important role in cell signaling by hydrolyzing cAMP and cGMP. PDEs can selectively regulate various cellular functions such as myocardial contraction , neurodegeneration , apoptosis , lipogenesis , glycogenolysis and gluconeogenesis. Thus PDE has the potential to become target of the treatment for various diseases , including depression,asthma,inflammation and erectile dysfunction etc. . Here is to make a brief review on the pharmacology of PDE related diseases.%磷酸二酯酶超家族(PDEs)是细胞内重要的第二信使cAMP和cGMP的催化水解酶.该家族参与大量的生理学过程,包括心肌收缩、神经退行性病变、细胞凋亡、脂肪生成、糖原分解和糖异生作用等.因此,PDE具有成为多种疾病治疗靶点的潜力,包括抑郁、哮喘、炎症与勃起功能障碍等.现就磷酸二酯酶相关疾病的药理学进展作简单的综述.