诱导性多能干细胞研究进展及应用前景

摘要

Reprogramming of induced pluripotent stem cells ( iPSCs ) is an important breakthrough in the field of regenerative medicine recently.It is achieved through transduction of exogenous transcription factors, into somatic cells, reprogramming the somatic cells to embryonic stem cells -like cells with potencies of unlimited proliferation and pluripotent differentiation.IPSCs derived from somatic cells of patients represent a powerful tool for biomedical research and may provide a source for replacement therapies.Here the research progress of iPSCs reprogramming and its medical prospect were emphasized.%将体细胞或成体干细胞重编程转变为诱导性多能干细胞(iPSCs)技术是近年来再生医学领域的重大进展.它是通过人工方法将适当的外源性转录因子导入体细胞或成体干细胞,使体细胞或成体干细胞转化为具有无限增殖潜能和定向分化能力、类似于胚胎干细胞的一类"人造干细胞".来源于特定患者体细胞的iPSCs为医学研究提供了强有力的工具,并有可能为损伤修复的替代治疗提供细胞来源.现重点讨论iPSCs在重编程过程中最新研究进展并概述了iPSCs的临床应用前景.