核因子κB在HBV相关性肝癌中的研究进展

摘要

It has been proved that hepatitis B virus infection is the main factor causing hepatocellular carcinoma( HCC ). The discovery of NF-κB set up a bridge between inflammation and tumor. NF-κB is activated by hepatitis B virus directly or indirectly,which then results in cancer by acting on carcinogens. The interaction is a negative feedback which is cascade amplified rather than unidirectional. Not only did NF-κB take part in the development in cancer,but also primary drug resistance. NF-κB plays a rather important role in HBV infection related hepatocellular carcinoma. The HBV-NF-κB-HCC clues will be reviewed in this article.%目前大量的研究证明,HBV感染是引起原发性肝癌的主要原因.核因子κB(NF-κB)的发现,在炎症和肿瘤之间搭起了一座桥梁.HBV通过自身直接或者间接引起NF-κB的激活,NF-κB又作用于致癌因子,从而引发肿瘤.但这种相互作用不是单向的,而是级联放大的负反馈.NF-κB不仅参与肝癌的发生、发展,还与化疗药物耐药有关,NF-κB在HBV感染引起的肝癌中的作用至关重要.