弥漫性肺骨化症的研究现状

摘要

Diffuse pulmonary ossification( DPO )is a very rare disease in clinical ,which is often misdiagnosed as other lung diseases. Recent studies indicate most of the cases are secondary to chronic lung disease ,while a few can he idiopathic. Cell and tissue injury , inflammation stimulation, alkaline environment , genetic predisposition and other factors participate in the pathogenesis. Cases of miliary , branch-like or coral-like calcification found in lungs through imaging test should be highly suspected as the disease; pathological examination of lung biopsy with mature ossification is an important identification basis of the disease.%弥漫性肺骨化症(DPO)临床上十分罕见,常被误诊为肺部其他疾病.本病多继发于慢性肺部疾病,少数可为特发性.细胞组织损伤、炎症刺激、碱性环境、遗传易感性等多种因素共同参与其发病过程.影像学肺内发现弥漫分布粟粒状、分支状或珊瑚礁状钙化影应高度怀疑为本病,肺活检病理学检查肺内有成熟骨化灶是确诊本病的重要依据.