目的 观察黛力新联合莫沙比利、兰索拉唑治疗功能性消化不良(FD)合并焦虑抑郁症的疗效.方法 对128例FD患者进行随机分组,对照组64例口服莫沙比利5 mg,每日3次+兰索拉唑30 mg,晨空腹顿服;治疗组64例口服莫沙比利5 mg,每日3次+兰索拉唑30 mg,晨空腹顿服+黛力新10.5 mg,每日2次,疗程均为8周.观察治疗前、后FD症状评分及抑郁自评量表(SDS)、焦虑自评量表(SAS)、胃肠道症状评定量表(GSRS)评分变化.结果 治疗组疗效优于对照组,差异有统计学意义(P﹤0.01).治疗组与对照组治疗前SDS、SAS、GSRS评分无明显差异,治疗后两组比较差异有统计学意义(P﹤0.01).药物起效时间治疗组明显快于对照组,两组相比有统计学意义(P＜0.01).结论 黛力新联合莫沙比利、兰索拉唑,对FD伴发抑郁焦虑症有显著的治疗作用.%Objective To investigate the therapeutic effect of deanxit combined with mosapride and lansoprazole treating patients with functional dyspepsia ( FD )with anxiety depression. Methods 128 cases of FD patients were randomly divided into two groups( test and control ). The control group( n = 64 )were treated with mosapride( 5 mg) three times a day and lansoprazole( 30 mg )on an empty stomach in the morning. The test group( n =64 )were added with deanxit( 10.5 mg )two times a day on the basis of the prescription of the control group. The course of treatment was 8 weeks. FD symptom grades and the changes of SDS, SAS and GSRS before and after the treatment in the two groups were compared. Results The therapeutic effect of the test group is better than the control group with statistically significant difference( P ＜ 0.01 ). SDS, SAS, GSRS of the two groups were without significant difference before treatment, but with significant difference after the treatment( P ＜ 0.01 ). Drug onset timein the test group is obviously shorter than in the control group with statistically significant difference( P ＜ 0.01 ). Conclusion Deanxit combined with mosapride and lansoprazole is significantly effective in treating functional dyspepsia with anxiety depression.
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