核心蛋白聚糖生物学的研究进展

摘要

核心蛋白聚糖(DCN)属富含亮氨酸小分子蛋白多糖家族成员之一.转化生长因子β(TGF-β)与其受体结合后导致细胞外基质过度沉积,DCN通过与TGF-β结合并将其中和以产生抗纤维化和抑制瘢痕形成的作用.同时DCN亦通过激活表皮生长因子受体(EGFR)/促分裂原活化蛋白激酶/p21信号通路和抑制EGF- EGFR介导的促细胞增殖信号通路等机制来抑制肿瘤细胞增殖与转移.基于DCN 以上两方面的生物活性,加之源于人体自身产生,所以重组产品免疫原性较低,提示DCN对于慢性纤维化和肿瘤等疾病的防治具有潜在的药用开发价值.%Decorin ( DCN ) is one of the leucine - rich proteoglycan familly of small molecules.Substantial evidence shows that DCN can interrupt transforming growth factor-β ( TGF-β ) binding to its receptor and reduce the excessive deposition of extracellular matrix.DCN plays an anti-fibrotic role and inhibits the formation of scar by binding or neutralizating TGF-β.DCN can also inhibit tumor cell proliferation and metastasis by activating epidermal growth factor receptor ( EGFR )/MAPK/p21 signaling pathway and inhibiting the signaling pathway that promotes cell proliferation by EGF-EGFR.Due to the above two biological activities and its human origin, recombinant DCN has a low immunogenicity, suggesting that DCN has a pharmacological potential in the treatment of chronic fibrosis and cancers.