莫西沙星治疗艾滋病合并下呼吸道感染的临床观察

摘要

目的探讨莫西沙星治疗敏感菌引起的艾滋病合并下呼吸道感染的疗效.方法将184例艾滋病合并下呼吸道感染患者随机分成两组,治疗组(n=94)予莫西沙星静脉滴注,对照组(n=90)予盐酸左氧氟沙星静脉滴注,疗程均为7 ～12 d.结果两组治疗效果比较差异有统计学意义(P＜0.05).细菌清除率:治疗组92.3%,对照组88.5%,两组比较差异无统计学意义(P＞0.05);不良反应发生率:治疗组4.3%,对照组5.6%,两组比较差异无统计学意义(P＞0.05).结论莫西沙星治疗艾滋病合并下呼吸道感染疗效确切,安全性好.%Objective To evaluate the efficacy and safety of moxifloxacin therapy in the treatment of patients with acquired immunodeficiency syndrome( AIDS )complicated with lower respiratory tract infection.Methods 184 patients with AIDS complicated with lower respiratory tract Infection were randomly divided into two groups. In treatment group( n = 94 ),moxifloxacin was administered by intravenous infusion. In control group( n = 90 ), levofloxacin was administered by intravenous infusion. The total treatment duration was 7 ～ 12 days. Results There was statistically significant difference( P ＜ 0.05 )in treatment effectiveness. The bacterial clearance rates were 92.3％ in treatment group,88.5％ in control group. There was no significant difference( P ＞ 0.05 ). The incidence of adverse drug reactions of two groups were 4.3％ in treatment group and 5.6％ in control group,respectively. There was no significant difference( P ＞ 0.05 ). Conclusion moxifloxacin intravenous infusion in the treatment of AIDS complicated with lower respiratory tract infection was more effective and safe.