耐多药肺结核病患者经氧氟沙星联合卷曲霉素治疗后干扰素γ和白细胞介素10水平的变化及意义

摘要

Objective To analysis the changes of IFN-γand IL-10's value of the patients who were Resisted to many medicine with tuberculosis( TB )before and after the treatment of levofloxacin joint curly amphotericin.Methods To check the value of IFN-γ( interferon γ )and interleukin ( IL )-10 )before and after the patients who were resisted to many medicine with TB treatment about levofloxacin joint curly amphotericin by adopting enzyme-linked immuno sorbent assay,and comparing with the control group.Results Before treatment, the activity value of IL-10 on the patients who were resisted to many medicine with TB is obviously higher than the sample in the control group,which the activity value of IFN-γon the patients who were resisted to many medicine with TB is obviously lower than the sample in the control group.After treatment,the activity value of IL-10 is obviously lower than that of before, and the activity value of IFN-γ is obviously higher than that of before, what's more, there is no obviously difference of the value of IFN-γand IL-10 between treatment group and control.Conclusion IFN-γand IL-10 play important roles in the anti-mycobacterium TB infection reaction,bring hope and breakthrough for TB treatment.%目的 分析耐多药肺结核(TB)患者经氧氟沙星联合卷曲霉素治疗前后血清干扰素γ(IFN-γ)和白细胞介素(IL-10)水平的变化.方法 采用酶联免疫吸附法(ELISA)检测86例耐多药肺结核患者经氧氟沙星联合卷曲霉素治疗前后 IFN-γ和IL-10水平,并与正常对照组比较.结果 治疗前,耐多药肺结核患者 IL-10活性水平较对照组明显增高(P＜0.05),IFN-γ活性水平较对照组明显降低(P＜0.05).治疗后,治疗组患者IL-10活性水平较化疗前明显降低(P＜0.05),治疗组患者IFN-γ活性水平较化疗前明显增高(P＜0.05),并且IFN-γ和IL-10水平与对照组无显著性差异(P＞0.05).结论 IFN-γ及IL-10在对抗结核分枝杆菌感染的反应中发挥着重要的作用,为结核病的治疗带来新的希望和突破.