During bone injury, local tissue or cells are often in a hypoxic state, and bone injury repair is a complex process subject to the regulation of a variety of cytokines. Hypoxia leads to a series of transcription-al expression of inducible factor,among which hypoxia inducible factor-1 a( HIF-1a )is a key factor to regulate cell response to hypoxia,many factors regulated by HIF-1a play a role in bone reparative process,mainly in angiogenesis and osteanagenesis. Here is to make a review on HIF-1 a effect on angiogenesis, osteoblast and osteoclast.%骨损伤时,局部组织或细胞常处于低氧状态,骨损伤修复是一个复杂的受多种细胞因子调控的修复过程.低氧导致一系列转录诱导因子的表达,其中低氧诱导因子(HIF-1α)是调节细胞低氧反应的关键因子,它所调控的一些因子在骨修复过程中作用十分广泛,主要涉及血管化和骨再生.现就HIF-1α的成血管作用,及其对成骨细胞、破骨细胞的调控作用予以综述.
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