ITCH的功能及其与疾病的关系

摘要

ITCH/AIP4( atrophin 1 interacting protein 4,referred to as AIP4 )was originally described from studies on mouse epidermis color. ITCH is a monomeric protein, which belongs to the homologous to E6-AP carboxy terminus( HECT )-type family of E3, involved in a variety of proteins ubiquitination degradation process in vivo, involved in immune response, participated in a variety of cellular processes, including cell cycle, proliferation and apoptosis;it plays a very important role in the process of tumor formation. Here is to make a review on the ITCH function and its relationship with diseases.%ITCH又称AIP4(atrophin 1 相互作用蛋白4),最初是在研究小鼠表皮颜色时被发现的.ITCH是一个单体蛋白,属于同源的HECT类型的泛素连接酶E3家族,参与体内多种蛋白质的泛素化降解过程;参与免疫反应;参与多种细胞过程,包括细胞循环、增殖和凋亡;在肿瘤的形成过程中发挥重要的作用.现就ITCH的功能及其与疾病的关系研究进展予以综述.