不同剂量阿托伐他汀治疗急性冠状动脉综合征临床疗效对比分析

摘要

Objective To Compare the rliniral curative effect of different doses of atorvastatin treatment of acute coronary art ray syndrome. Methods 98 patients with acute coronary syndrome in Suzhou Jiulong Hospital were selected and divided into control group( including 48 patients given 20 mg/d atorvastatin for 6 months )and observation group( including 50 patients given 40 mg/d atorvastatin for 6 months ). The treatment was done for 6 months consecutively, and serum lipids, hs-CRP levels and the incidence of major cardiovascular events after discharge of the two groups were observed. Results After treatment, TC , LDL-C and hs-CR level of the two groups descended and HDL-C rose( P ＜ 0. 05 ). TC , LDL-C and hs-CR of the observation group were lower than the control group and HDL-C was higher, with statistically significant difference( Prn＜ 0.05 ). The rate of major cardiovascular events of the observation group was lower the control group( Prn＜ 0. 05 ). Conclusion Larger dose of atorvastatin( 40 mg/d )can improve the lipid levels, reduce the inci-dence rate oi major adverse cardiovascular and cerebrolvascular events oi the acute coronary syndrome patients,with significant clinical efficacy.%目的比较不同剂量的阿伐他汀治疗急性冠状动脉综合征的临床疗效.方法 选择苏州市九龙医院确诊的急性冠状动脉综合征患者98例,按照随机原则分为对照组48例和观察组50例,两组在给予常规对症治疗的基础上,对照组给予阿伐他汀20 mg/d,观察组给予 40 mg/d.连续服用6个月后,观察两组患者治疗前后以及两组之间的血脂指标、hs-CRP水平以及出院后的主要心血管事件发生率的变化.结果 与治疗前相比,两组患者治疗后的TC、LDL-C以及hs-CRP水平显著下降,HDL-C水平则显著上升(P<0.05).两组相比,观察组TC、LDL-C、hs-CRP水平下降,HDL-C水平上升优于对照组,比较差异有统计学意义.主要心血管事件发生率观察组低于对照组(P<0.05).结论 较大剂量阿托伐他汀(40 mg/d)能够显著改善急性冠状动脉综合征患者的血脂水平,降低心脑血管事件发生率,临床效果显著.