Objective To evaluate the effects and safety of dezocine in intravenous analgesia for postoperative pain by radical mastectomy. Methods 80 patients were divided into two groups randomly, each 40, and were given dezocine and fentanyl for intravenous analgesia,respectively. The analgesia scores and sedation scores were recorded at 5 defined intervals for evaluation, and the adverse effects were recorded as well. Results There was no significant difference between the two groups in analgesia scores and desired analgesia rates respectively( P > 0. 05 ), whereas the sedation scores at 4h and 8h intervals were obviously higher in the fentanyl group( P<0.01 ). Furthermore, the adverse effect incidence in the fentanyl group was higher than that in the dezocine group. Conclusion The clinical effects of dezocine for postoperative pain is equivalent to fentanyl,whilst it introduces appropriate sedation and lower adverse effect incidences. Consequently,it can be used in intravenous analgesia for postoperative pain by radical mastectomy safely and efficiently.%目的 观察地佐辛注射液对乳腺癌根治术患者的术后静脉镇痛的疗效.方法 将80例乳腺癌根治术患者随机分成地佐辛和芬太尼两组,每组各40例,分别给予地佐辛注射液和芬太尼注射液进行术后静脉镇痛,并记录术后5个时点的镇痛评分和镇静评分作为评估参考,同时记录不良反应例数.结果 两组患者的镇痛评分和镇痛优良率无显著性差异(P＞0.05),但芬太尼组在术后4、8 h的镇静评分明显高于地佐辛组(P＜0.01).芬太尼组的不良反应记录亦明显高于地佐辛组.结论 地佐辛具有和芬太尼相当的镇痛效果,且镇静程度适当,并且不良反应明显少于芬太尼,可安全、有效地用于乳腺癌根治术患者的术后静脉镇痛.
展开▼
