乙型肝炎病毒X蛋白在肝细胞癌发生发展中的作用

摘要

乙型肝炎病毒(HBV)感染是急慢性病毒性肝炎的主要致病因素,它也是诱发肝硬化,原发性肝细胞癌(HCC)的重要危险因素.据世界卫生组织(WHO)统计,每年全球范围内约有4亿人受到HBV的慢性感染,而约有1亿人死于HBV感染.乙型肝炎病毒X蛋白(HBx)是由乙型肝炎病毒X基因编码的一个由154个氨基酸组成的多功能反式激活蛋白,在病毒的复制和肿瘤的形成和发展中发挥着极其重要的作用,大量研究表明HBx与肝细胞癌的发生、发展有着密切的关系.%Hepatitis B virus( HBV )infection is the main pathogenic factor of acute or chronic viral hepatitis, which is also the important risk factor of liver cirrhosis and primary hepatocellular carcinoma( HCC ). The World Health Organization( WHO ) estimates that there are currently 400 million individuals worldwide who are chronically infected, of whom 100 million will eventually die. The hepatitis B virus X protein( HBx ), a 154-amino acid encoded by HBV X genome is a promiscuous transactivator,which plays a very important role in the viral replication and tumor formation, with a lot of research showing that HBx has a close relationship with the hepatocellular cancer's occurrence and development.