坎地沙坦对不稳定型心绞痛患者相关炎性因子及预后的影响分析

摘要

目的 探讨坎地沙坦对不稳定型心绞痛患者相关炎性因子及预后的影响.方法 选择不稳定型心绞痛患者80例,随机分为观察组和对照组.对照组采用常规治疗,观察组在对照组基础上应用坎地沙坦.结果 观察组治疗后干扰素γ、白细胞介素2水平与对照组治疗后比较,差异有统计学意义(P＜0.05);观察组主要心脏不良事件发生率显著低于对照组,差异有统计学意义(P＜0.05).结论 坎地沙坦能显著降低不稳定型心绞痛患者不良心脏事件发生率,改善预后,可能与其抑制炎性反应有关.%Objective To explore the effect of candesartan on inflammatory factors and prognosis in patients with unstable angina. Methods 80 cases with unstable angina were selected and divided into observation group and control group. The routine therapy was used to the control group, and candesartan was given to the observation group on the base of the routine therapy. Results The level of interferon-y and interleukin-2 in the observation group after treatment compared with those in the control group,there was statistical differ-ence( P <0.05 ). The survival rate of the major adverse cardiac events in the observation group was lower than that in the control group,there was statistical difference between the two groups( P <0.05 ). Conclusion Candesartan can decrease the the major adverse cardiac events of unstable angina, and improve the prognosis, which may be related with the inhibition of inflammatory response.