Salusins are novel bioactive peptides with hypotension and mitogenic activities,which ubiquitously expressed in kinds of tissues including, hematopoietic system, endocrine system and central nervous system. Recent studies indicate the expression of salusin-a in rat. The distributions of salusin-a and salusin-(3 in rat are tissue-specific. Both salusin-a and salusin-p regulates blood pressure and heart rate by brain mechanism, inhibits ventricular myocytes calcium currents, protects ischemic myocardium, and enhances the proliferation of vascular smooth muscle cells. Salusins could be the underlying pathophysiological mechanism of atherosclerosis.%Salusins是主要存在于造血系统、内分泌系统和中枢神经系统具有降低血压和丝裂原样效应的生物活性肽.近年来研究表明Salusin-α在大鼠体内表达,Salusin-α和salusin-β在大鼠体内的分布具有组织特异性.Salusins可能通过中枢调节血压和心率,抑制心室肌细胞钙通道电流,发挥缺血心肌保护效应和血管平滑肌的增殖作用,可能参与动脉粥样硬化等心血管疾病的病理生理学过程.
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