乌司他丁在脑卒中后脑损伤中的抗炎作用

摘要

脑卒中是一组由于脑组织局部缺血和(或)出血造成脑组织损伤为主要临床表现的疾病.常遗留严重的后遗症,影响患者的生存质量.近年来发现,脑卒中后病情的恶化往往与继发的脑水肿、炎性反应的损伤有关.证据表明,乌司他丁可以通过抑制Toll样受体,减少核因子κB的表达,降低局部炎性细胞因子的释放,抑制继发性炎性反应,从而在脑卒中后起到重要的神经保护作用.%Stroke is a group of disease with brain tissue damage as the main clinical manifestations, caused by brain tissue ischemia and/or hemorrhage. There often are serious consequences,affecting patients' quality of life. Discovered in recent years, post-stroke deterioration of the condition is often associated with secondary brain edema and the injury of inflammation. Evidence suggests that ulinastatin can inhibit Toll-like receptor,reduce the expression of NF-kB and the local release of inflammatory cytokines,thus inhibit the secondary inflammatory response,which play an important neuroprotective effect after stroke.