α突触核蛋白与神经系统疾病的关系研究进展

摘要

α-synuclein is a small molecule of acid soluble proteins,the incidence of the pathological ba-sis of Parkinson′s disease,plays an important role in the genesis of Parkinson′s disease. Aspects of this pa-per,the α-synuclein structure, function and lead to the pathogenesis of Parkinson′s disease were reviewed, combined with recent hereditary spinocerebellar ataxia (SCA2) 2 andα-synaptic nuclear protein-to illustrate whether hereditary spinocerebellar ataxia (SCA2) 2 with the onset of Parkinson′s symptoms have a common basis of the incidence and onset of Parkinson′s disease, whether it is abnormal aggregation of α-synuclein due,pending further research.%α突触核蛋白(α-Syn)是一种小分子酸性可溶性蛋白，是帕金森病发病的病理基础，在帕金森病的发生中起着重要作用。该文对α-Syn的结构、功能及其导致帕金森病的发病机制等方面进行了综述，结合近年来对遗传性脊髓小脑型共济失调2型(SCA2)与α-Syn关系的研究来阐述带有帕金森症状的SCA2的发病是否与帕金森病的发病有共同的发病基础，是否也是α-Syn异常聚集所致，尚待进一步考证。