狼疮肾炎的药物治疗进展

摘要

Lupus nephritis is involved by SLE and caused by immune complexes,is one of the most often involving organs of systemic lupus erythematosus,also is the most common secondery glomerular disease. In recent years,as the study of pathogenesis of lupus nephritis and the application of the renal biopsy, lupus ne-phritis patients' survival rate has improved significantly,but given recurrence of lupus nephritis and side effects in the process of application of various immune suppression,the treatment of lupus nephritis there is still a challenge. The purpose of this paper is to review existing and new drug treatment of lupus nephritis.%狼疮肾炎是系统性红斑狼疮累及肾脏所引起的一种免疫复合物性肾炎，是最常见的继发性肾小球疾病。近年来，随着对狼疮肾炎发病机制的研究及肾活检的应用，狼疮肾炎的治疗已取得了可观的效果，狼疮肾炎患者的生存率已显著提高，但是由于狼疮肾炎存在复发及治疗过程中应用各种免疫抑制剂所引起的不良反应，狼疮肾炎的治疗仍存在挑战。该文就狼疮肾炎的药物治疗进展予以综述。